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dc.contributor.authorKennedy, Karen
dc.contributor.authorMacova, Miroslava
dc.contributor.authorBartkow, Michael E
dc.contributor.authorHawker, Darryl W
dc.contributor.authorZhao, Bin
dc.contributor.authorDenison, Michael S
dc.contributor.authorMueller, Jochen F
dc.date.accessioned2017-05-03T11:24:32Z
dc.date.available2017-05-03T11:24:32Z
dc.date.issued2010
dc.date.modified2010-09-22T06:54:47Z
dc.identifier.issn1309-1042
dc.identifier.doi10.5094/APR.2010.008
dc.identifier.urihttp://hdl.handle.net/10072/32194
dc.description.abstractThere has been relatively little bioanalytical effect based monitoring conducted using samples derived from polyurethane foam (PUF) passive air samplers. Combining these techniques may provide a more convenient and cost effective means of monitoring the potential for biological effects resulting from exposure to complex mixtures in a range of scenarios. Seasonal polycyclic aromatic hydrocarbon (PAH) levels were monitored at sites around Australia using direct chemical analysis. In addition, both indirect acting genotoxicity (umuC assay) and aryl hydrocarbon receptor (AhR) activity (chemically activated fluorescent gene expression [CAFLUX assay]), which are effects potentially relevant to subsequent carcinogenesis for these compounds, were measured. The levels of PAHs as well as genotoxicity and AhR activity were all higher in winter compared to summer and for sites in urban capital cities compared to other locations. Statistically significant relationships were found between the levels of PAHs and both genotoxicity and AhR activity. The dominant contributors to the total AhR activity, were found to be for compounds which are not resistant to H2SO4/silica gel treatment and were relatively rapidly metabolised that is consistent with a PAH type response. Relative potency estimates for individual PAHs determined for the first time on the CAFLUX assay were used to estimate the proportion of total AhR activity (= 3.0%) accounted by PAHs monitored. Observed responses are thus largely due to non-quantified AhR active compounds.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent403791 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherTurkish National Committee for Air Pollution Research and Control (TUNCAP)
dc.publisher.placeTurkey
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom50
dc.relation.ispartofpageto58
dc.relation.ispartofissue1
dc.relation.ispartofjournalAtmospheric Pollution Research
dc.relation.ispartofvolume1
dc.rights.retentionY
dc.subject.fieldofresearchAtmospheric composition, chemistry and processes
dc.subject.fieldofresearchAtmospheric sciences
dc.subject.fieldofresearchEnvironmental engineering
dc.subject.fieldofresearchcode370104
dc.subject.fieldofresearchcode3701
dc.subject.fieldofresearchcode4011
dc.titleEffect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© The Author(s) 2010. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal's website or contact the authors.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorHawker, Darryl W.


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