Synthesis of N-Propargyl Iminosugar Scaffolds for Compound Library Generation using Click Chemistry
Author(s)
Wilkinson, Brendan L
Bornaghi, Laurent F
Lopez, Marie
Healy, Peter C
Poulsen, Sally-Ann
Houston, Todd A
Year published
2010
Metadata
Show full item recordAbstract
We have developed an efficient synthesis of N-propargyl iminosugars for use in diversity-oriented library development. Through a common, crystalline intermediate both piperidine and azepane scaffolds can be prepared with an alkyne functional group, allowing for further elaboration through reaction with azides.We have developed an efficient synthesis of N-propargyl iminosugars for use in diversity-oriented library development. Through a common, crystalline intermediate both piperidine and azepane scaffolds can be prepared with an alkyne functional group, allowing for further elaboration through reaction with azides.
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Journal Title
Australian Journal of Chemistry
Volume
63
Issue
5
Subject
Chemical sciences
Biologically active molecules
Engineering