Synthesis of N-Propargyl Iminosugar Scaffolds for Compound Library Generation using Click Chemistry

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Title Synthesis of N-Propargyl Iminosugar Scaffolds for Compound Library Generation using Click Chemistry
Author Wilkinson, Brendan Luke; Bornaghi, Laurent; Lopez, Marie; Healy, Peter Conrad; Poulsen, Sally-Ann; Houston, Todd Ashley
Journal Name Australian Journal of Chemistry
Year Published 2010
Place of publication Australia
Publisher CSIRO Publishing
Abstract We have developed an efficient synthesis of N-propargyl iminosugars for use in diversity-oriented library development. Through a common, crystalline intermediate both piperidine and azepane scaffolds can be prepared with an alkyne functional group, allowing for further elaboration through reaction with azides.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1071/CH09426
Volume 63
Issue Number 5
Page from 821
Page to 829
ISSN 0004-9425
Date Accessioned 2010-06-10
Language en_AU
Research Centre Eskitis Institute for Drug Discovery; Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Biologically Active Molecules
URI http://hdl.handle.net/10072/32201
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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