Молекулярно-Генетическая характеристика штамма A/chicken/Moscow/2/2007 (H5N1) из очага эпизоотии высокопатогенного гриппа А среди сельскохозяйственных птиц в Подмосковье (февраль 2007 г.)

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Title Молекулярно-Генетическая характеристика штамма A/chicken/Moscow/2/2007 (H5N1) из очага эпизоотии высокопатогенного гриппа А среди сельскохозяйственных птиц в Подмосковье (февраль 2007 г.)
Author Lvov, D.K.; Shchelkanov, M.Yu.; Prilipov, A. G.; Deryabin, P. G.; Akanina, D. S.; Galkina, I. G.; Grebennikova, T. V.; Fedyakina, I.T.; Alkhovsky, S.V.; Usacheva, O. V.; Kireyev, D.Ye.; Slavsky, A. A.; Starikov, N.S.; Petrenko, M.S.; Mikhailova, V.V.; Usachev, Evgeny; Sadykova, G.K.; Morozova, T.N.; Samokhvalov, Ye.I.; Yudin, A.N.; Vitkova, O.N.; Shcherbakova, L.O.; Zaberezhnyi, A.D.; Kalmykov, M.V.; Gromashevsky, V. L.; Aliper, T.I.; Yakovlev, S. S.; Vlasov, N.A.; Nepoklonov, Ye.A.; Suarez, D.
Journal Name Voprosy Virusologii
Year Published 2007
Place of publication Russian Federation
Publisher Izdatel'stvo Meditsina
Abstract Among agricultural birds in the near-Moscow Region (February 2007), local epizootics caused by the highly pathogenic avian influenza A/H5N1 virus seem to be of unintended manual origin. Such a situation may be considered to be model when the source of inoculation is elucidated in cases of potentially possible acts of bioterrorism. Molecular genetic analysis of isolated A/chicken/Moscow/2/2007 strain established its genetic similarity with the highly pathogenic strains detected in the Black-and-Caspian Sea region in 2006. At the same time, comparison of nucleotide sequences of the strain A/chicken/Moscow/2/2007 with the strains of Qinghai-Siberian genotype (CSG) for which the sequences of full-sized genomes are known in the international databases revealed a significant distinction of the near-Moscow strain from the earlier known analogues. The uniqueness of the primary structure of the PB1 gene is shown. The paper discusses the functional value of amino acid substitutions in the proteins of the strain A/chicken/Moscow/2/2007 and in other variants of CSG of the subtype H5N1.
Peer Reviewed Yes
Published Yes
Volume 52
Issue Number 6
Page from 40
Page to 47
ISSN 0507-4088
Date Accessioned 2010-03-25
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Cross discipline
URI http://hdl.handle.net/10072/32985
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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