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dc.contributor.authorD. Swagell, Christopher
dc.contributor.authorC. Henly, Debra
dc.contributor.authorPhillip Morris, C.
dc.date.accessioned2017-05-03T15:52:27Z
dc.date.available2017-05-03T15:52:27Z
dc.date.issued2005
dc.date.modified2010-08-13T07:23:24Z
dc.identifier.issn0006291X
dc.identifier.doi10.1016/j.bbrc.2004.12.188
dc.identifier.urihttp://hdl.handle.net/10072/33006
dc.description.abstractSaturated fat plays a role in common debilitating diseases such as obesity, type 2 diabetes, and coronary heart disease. It is also clear that certain fatty acids act as regulators of metabolism via both direct and indirect signalling of target tissues. As the molecular mechanisms of saturated fatty acid signalling in the liver are poorly defined, hepatic gene expression analysis was undertaken in a human hepatocyte cell line after incubation with palmitate. Profiling of mRNA expression using cDNA microarray analysis revealed that 162 of approximately 18,000 genes tested were differentially expressed after incubation with palmitate for 48 h. Altered transcription profiles were observed in a wide variety of genes, including genes involved in lipid and cholesterol transport, cholesterol catabolism, cell growth and proliferation, cell signalling, ߭oxidation, and oxidative stress response. While palmitate signalling has been examined in pancreatic ߭cells, this is the first report showing that palmitate regulates expression of numerous genes via direct molecular signalling mechanisms in liver cells.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAcademic Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom432
dc.relation.ispartofpageto441
dc.relation.ispartofissue2
dc.relation.ispartofjournalBiochemical and biophysical research communications
dc.relation.ispartofvolume328
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classified
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchcode030499
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.titleExpression analysis of a human hepatic cell line in response to palmitate
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorHenly, Debra


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