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dc.contributor.authorZhang, Wenbao
dc.contributor.authorZhang, Zhuangzhi
dc.contributor.authorYimit, Turhong
dc.contributor.authorShi, Baoxin
dc.contributor.authorAili, Hasyeti
dc.contributor.authorTulson, Gulnor
dc.contributor.authorYou, Hong
dc.contributor.authorLi, Jun
dc.contributor.authorGray, Darren
dc.contributor.authorMcManus, Don
dc.contributor.authorWang, Jincheng
dc.date.accessioned2017-05-03T14:01:25Z
dc.date.available2017-05-03T14:01:25Z
dc.date.issued2009
dc.date.modified2010-10-19T06:59:25Z
dc.identifier.issn19352735
dc.identifier.doi10.1371/journal.pntd.0000534
dc.identifier.urihttp://hdl.handle.net/10072/33017
dc.description.abstractBackground: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. Methodology/Principal Findings: A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. Conclusions/Significance: The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent209723 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome534-1
dc.relation.ispartofpagetoe534-7
dc.relation.ispartofissue10
dc.relation.ispartofjournalPLoS Neglected Tropical Diseases
dc.relation.ispartofvolume3
dc.rights.retentionY
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111706
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleA Pilot Study for Control of Hyperendemic Cystic Hydatid Disease in China
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://www.plos.org/journals/license.html
gro.rights.copyright© 2009 McManus et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CCAL. (http://www.plos.org/journals/license.html)
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorGray, Darren
gro.griffith.authorMcManus, Don P.


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