Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China

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Title Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China
Author Yang, Yu Rong; Gray, Darren; Ellis, Magda K; Yang, Shu Kun; Craig, Philip S; McManus, Donald Peter
Journal Name Parasites & Vectors
Year Published 2009
Place of publication United Kingdom
Publisher BioMed Central
Abstract Abstract During analysis of retrospective community survey data, we identified two patients from Xiji County, south Ningxia Hui Autonomous Region with simultaneous echinococcosis and tuberculosis (TB), representing the first such reports for China. As the echinococcosis chronicity increased, the immune profile in both subjects changed from a Th1 to Th2 response, as shown by a TB skin test, originally positive, becoming negative. Such an elevated Th2 immune profile, with subsequent suppression of the Th1 immune response, is a common feature of chronic helminth infections. Given the difficulties in definitive diagnosis, and the potential increased susceptibility for TB infection in patients with advanced echinococcosis, we suggest that combined TB/echinococcosis surveys be undertaken in this area in the future. This would allow early diagnosis of both TB and echinococcosis cases with better prognosis for effective and sustainable treatment outcomes, ultimately reducing associated morbidity and mortality, and also the overall financial costs to the individual and the public health care system in this under developed part of China.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2009 Gray et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Volume 2
Page from 1
Page to 5
ISSN 1756-3305
Date Accessioned 2010-06-23
Language en_AU
Faculty Griffith Health Faculty
Subject Medical Parasitology
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1a

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