Influence of age and carriage status on salivary IgA to Neisseria meningitidis

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Title Influence of age and carriage status on salivary IgA to Neisseria meningitidis
Author Horton, Rachel Elizabeth; Stuart, J.; Christensen, H.; Borrow, R.; Guthrie, T.; Davenport, V.; Finn, A.; team, ALSPAC study; Williams, N.A.; Heyderman, R.S.
Journal Name Epidemiology and Infection
Year Published 2005
Place of publication United Kingdom
Publisher Cambridge University Press
Abstract Asymptomatic carriage of Neisseria meningitidis is common (5–35% of individuals) while the incidence of invasive meningococcal disease is fairly low (<1–5 per 100 000 per annum in Europe). Naturally acquired protective immunity may account for this difference. In this study, we investigated the relationship between anti-meningococcal salivary IgA and age and carriage. We showed that salivary IgA to a range of meningococcal antigens increased successively with age with some specificity for commonly circulating serosubtypes. In a group of 258 students 37 (14%) of whom were carriers of N. meningitidis serogroup B, higher levels of specific IgA were associated with carriage. Stratified analysis revealed a positive relationship between smoking and specific anti-N. meningitidis IgA independent of current carriage, weighted odds ratio (OR) 4.1 (95% CI 1.1–18) and OR 3.8 (95% CI 0.96–16) for reference strains B:1:P1.14 and B:4:P1.5,4 respectively. These data implicate IgA as a factor in host defence from meningococcal invasion, although the precise mechanisms remain uncertain.
Peer Reviewed Yes
Published Yes
Volume 133
Issue Number 5
Page from 883
Page to 889
ISSN 0950-2688
Date Accessioned 2010-07-16
Date Available 2010-07-30T07:20:46Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medical Infection Agents (incl Prions)
URI http://hdl.handle.net/10072/33105
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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