Antibacterial Metabolites from Australian Macrofungi from the Genus Cortinarius

There are no files associated with this record.

Title Antibacterial Metabolites from Australian Macrofungi from the Genus Cortinarius
Author Beattie, Karren; Rouf, Razina; Gander, Louisa Jane; May, Tom W.; Ratkowsky, David; Donner, Christopher D.; Gill, Melvyn; Grice, Darren; Tiralongo, Evelin
Journal Name Phytochemistry
Year Published 2010
Place of publication United Kingdom
Publisher Elsevier
Abstract In this study, ethyl acetate and aqueous fractions from 117 collections of Australian macrofungi belonging to the mushroom genus Cortinarius were screened for antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Overall, the lipophilic fractions were more active than the aqueous fractions. The ethyl acetate fractions of most or all collections of 13 species, namely Cortinarius ardesiacus, C. archeri, C. austrosaginus, C. austrovenetus, C. austroviolaceus, C. coelopus, C. [Dermocybe canaria]2, C. clelandii, C. [D. kula], C. memoria-annae, C. persplendidus, C. sinapicolor, C. vinosipes and forty seven collections of un-described Cortinarius species exhibited IC50 values of less-than-or-equals, slant0.09 mg/mL against S. aureus. In contrast, most or all collections of only four species, namely C. abnormis, C. austroalbidus, C. [D. kula], C. persplendidus, and eleven un-described Cortinarius collections exhibited similar effects against P. aeruginosa (IC50 less-than-or-equals, slant 0.09 mg/mL). Anthraquinonoid pigments isolated from C. basirubescens together with emodin physcion and erythrogluacin were assessed for their antimicrobial activity. The fungal octaketides austrocortilutein, austrocortirubin, torosachrysone, physcion and emodin were found to strongly inhibit the growth of S. aureus (IC50 0.7–12 μg/mL) whereas only physcion and emodin exhibited potency against P. aeruginosa (IC50 1.5 and 2.0 μg/mL, respectively).
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.phytochem.2010.03.016
Volume 71
Issue Number 8-9
Page from 948
Page to 955
ISSN 0031-9422
Date Accessioned 2010-06-24
Date Available 2010-08-04T02:38:13Z
Language en_AU
Research Centre Griffith Health Institute; Eskitis Institute for Drug Discovery; Institute for Glycomics; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Complementary and Alternative Medicine
URI http://hdl.handle.net/10072/33245
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

Brief Record

Griffith University copyright notice