GAEC1 and colorectal cancer: a study of the relationships between a novel oncogene and clinicopathologic features

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Title GAEC1 and colorectal cancer: a study of the relationships between a novel oncogene and clinicopathologic features
Author Gopalan Chettiyar Padmam, Vinod; Smith, Robert Anthony; Nassiri, Mohammad R.; Yasuda, Koichi; Salajegheh, Ali; Kim, Sang Y.; Ho, Yik-Hong; Weinstein, Stephen Rudolph; Tang, Johnny C.-O.; Lam, Alfred
Journal Name Human Pathology
Editor Ricardo V Lloyd
Year Published 2010
Place of publication United States
Publisher W.B. Saunders & Co.
Abstract GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The copy number of GAEC1 was studied by evaluating the quantitative amplification of GAEC1 DNA in 259 colorectal tissues (144 adenocarcinomas, 31 adenomas, and 84 nonneoplastic tissues) using real-time polymerase chain reaction. Copy number of GAEC1 DNA in colorectal adenocarcinomas was higher in comparison with nonneoplastic colorectum. Seventy-nine percent of the colorectal adenocarcinomas showed amplification and 15% showed deletion of GAEC1 (P < .0001). Of the adenomas, 90% showed deletion of GAEC1, with the remaining 10% showing normal copy number. The differences in GAEC1 copy number between colorectal adenocarcinoma, colorectal adenoma, and nonneoplastic colorectal tissue are significant (P < .0001). GAEC1 copy number was significantly higher in adenocarcinomas located in distal colorectum compared with proximal colon (P = .03). In conclusion, GAEC1 copy number was significantly different between colorectal adenocarcinomas, adenomas, and nonneoplastic colorectal tissues. The copy number was also related to the site of the cancer. These findings along with previous work in esophageal cancer imply that GAEC1 is commonly involved in the pathogenesis of colorectal adenocarcinoma. Copyright 2010 Elsevier Inc. All rights reserved.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.humpath.2009.11.014
Copyright Statement Copyright 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 41
Issue Number 7
Page from 1009
Page to 1015
ISSN 0046-8177
Date Accessioned 2010-07-08
Date Available 2010-10-20T07:01:02Z
Language en_AU
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Pathology (excl Oral Pathology)
URI http://hdl.handle.net/10072/33277
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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