Katayama syndrome

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Title Katayama syndrome
Author Ross, Allen Guy Patrick; Vickers, David; Olds, G Richard; Shah, Syed M; McManus, Donald P
Journal Name Lancet Infectious Diseases
Year Published 2007
Place of publication United Kingdom
Publisher The Lancet Publishing Group
Abstract Katayama syndrome is an early clinical manifestation of schistosomiasis that occurs several weeks post-infection with Schistosoma spp (trematode) worms. Because of this temporal delay and its non-specific presentation, it is the form of schistosomiasis most likely to be misdiagnosed by travel medicine physicians and infectious disease specialists in non-endemic countries. Katayama syndrome appears between 14–84 days after non-immune individuals are exposed to first schistosome infection or heavy reinfection. Disease onset appears to be related to migrating schistosomula and egg deposition with individuals typically presenting with nocturnal fever, cough, myalgia, headache, and abdominal tenderness. Serum antibodies and schistosome egg excretion often substantiate infection if detected. Diffuse pulmonary infiltrates are found radiologically, and almost all cases have eosinophilia and a history of water contact 14–84 days before presentation of clinical symptoms; patients respond well to regimens of praziquantel with and without steroids. Artemisinin treatment given early after exposure may decrease the risk of the syndrome.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/S1473-3099(07)70053-1
Volume 7
Issue Number 3
Page from 218
Page to 224
ISSN 1473-3099
Date Accessioned 2010-03-16
Language en_AU
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Medical Microbiology
URI http://hdl.handle.net/10072/33425
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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