Cardiovascular biology of the A3 adenosine receptor

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Title Cardiovascular biology of the A3 adenosine receptor
Author Headrick, John Patrick; Peart, Jason Nigel John; Wang, Tina C.; Kwok, Wai-Meng; Auchampach, John A.
Book Title A3 Adenosine Receptors: from Cell Biology to Pharmacology and Therapeutics
Editor PA Borea
Year Published 2010
Place of publication Dordrecht
Publisher Springer
Abstract The goal of this chapter is to review current theories regarding the potential involvement of the A3 receptor in mediating the actions of adenosine in the cardiovascular system. The Gi protein-coupled A3 adenosine receptor is the last adenosine receptor subtype to be discovered and remains poorly characterized in terms of its molecular biology and biological functions (Linden 1994). Recent evidence suggests that the A3 receptor may mediate the actions of adenosine to regulate vascular tone and angiogenesis, either directly or indirectly by stimulating the release of mediators from mast cells. Substantial evidence has accumulated to suggest that the A3 receptor is responsible for some of the beneficial effects of adenosine in reducing injury caused by ischemia and reperfusion. Readers are reminded that the A3 receptor has proven to be the most difficult adenosine receptor subtype to research due to its unique pharmacological properties and unusual species differences in terms of its pharmacology, tissue expression, and biological function (Linden 1994). The theories described in this chapter remain controversial and require additional verification as new tools become available to study this fascinating member of the adenosine receptor family.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.springerlink.com
Alternative URI http://dx.doi.org/10.1007/978-90-481-3144-0_10
Chapter Number 10
Page from 189
Page to 208
ISBN 9789048131433
Date Accessioned 2010-03-03
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Clinical Pharmacology and Therapeutics
URI http://hdl.handle.net/10072/33707
Publication Type Book Chapters
Publication Type Code b1

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