Esterase D Is Essential for Protection of Neisseria gonorrhoeae against Nitrosative Stress and for Bacterial Growth during Interaction with Cervical Epithelial Cells
Author(s)
Potter, Adam J
Kidd, Stephen P
Edwards, Jennifer L
Falsetta, Megan L
Apicella, Michael A
Jennings, Michael P
McEwan, Alastair G
Griffith University Author(s)
Year published
2009
Metadata
Show full item recordAbstract
estD encodes a carboxylic ester hydrolase and is part of the NmlR regulon in Neisseria gonorrhoeae. An estD mutant was found to be susceptible to nitrite and to S-nitrosoglutathione. This mutant was also unable to infect and survive within human cervical epithelial cells, and it showed reduced ability to form a biofilm on these cells. We conclude that esterase D is an integral part of the nitrosative stress defense system of N. gonorrhoeae and that it has potential importance in pathogenesis.estD encodes a carboxylic ester hydrolase and is part of the NmlR regulon in Neisseria gonorrhoeae. An estD mutant was found to be susceptible to nitrite and to S-nitrosoglutathione. This mutant was also unable to infect and survive within human cervical epithelial cells, and it showed reduced ability to form a biofilm on these cells. We conclude that esterase D is an integral part of the nitrosative stress defense system of N. gonorrhoeae and that it has potential importance in pathogenesis.
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Journal Title
The Journal of Infectious Diseases
Volume
200
Issue
2
Subject
Biological sciences
Infectious agents
Biomedical and clinical sciences