Esterase D Is Essential for Protection of Neisseria gonorrhoeae against Nitrosative Stress and for Bacterial Growth during Interaction with Cervical Epithelial Cells

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Title Esterase D Is Essential for Protection of Neisseria gonorrhoeae against Nitrosative Stress and for Bacterial Growth during Interaction with Cervical Epithelial Cells
Author Potter, Adam J.; Kidd, Stephen P.; Edwards, Jennifer L.; Falsetta, Megan L.; Apicella, Michael A.; Jennings, Michael Paul; McEwan, Alastair G.
Journal Name The Journal of Infectious Diseases
Year Published 2009
Place of publication United States
Publisher University of Chicago Press
Abstract estD encodes a carboxylic ester hydrolase and is part of the NmlR regulon in Neisseria gonorrhoeae. An estD mutant was found to be susceptible to nitrite and to S-nitrosoglutathione. This mutant was also unable to infect and survive within human cervical epithelial cells, and it showed reduced ability to form a biofilm on these cells. We conclude that esterase D is an integral part of the nitrosative stress defense system of N. gonorrhoeae and that it has potential importance in pathogenesis.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1086/599987
Volume 200
Issue Number 2
Page from 273
Page to 278
ISSN 0022-1899
Date Accessioned 2010-02-18
Date Available 2010-09-10T05:18:09Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/33883
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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