Cervical HIV-Specific IgA in a Population of Commercial Sex Workers Correlates with Repeated Exposure But Not Resistance to HIV

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Title Cervical HIV-Specific IgA in a Population of Commercial Sex Workers Correlates with Repeated Exposure But Not Resistance to HIV
Author Horton, Rachel Elizabeth; Ball, T. Blake; Wachichi, Charles; Jaoko, Walter; Rutherford, W. John; Mckinnon, Lyle; Kaul, Rupert; Rebbapragada, Anu; Kimani, Joshua; Plummer, Frank A.
Journal Name AIDS Research and Human Retroviruses
Year Published 2009
Place of publication United States
Publisher Mary Ann Liebert, Inc. Publishers
Abstract We conducted a comprehensive cross-sectional analysis of total and HIV-specific cervical antibody levels in HIV- 1-resistant, uninfected, and infected women in order to examine the role of HIV-specific antibody responses in the female genital tract and examine the effect on antibody levels of various epidemiologic factors in this population. Cervical lavages were collected from 272 subjects of the Pumwani commercial sex worker cohort. Total and HIV-specific genital tract IgA and IgG levels were measured using an ELISA and correlated with behavioral and demographic factors. No significant difference was seen between cervical HIV-specific IgA levels in infected, uninfected, and resistant individuals, nor were any correlations between cervical HIV-specific IgA and neutralization capacity or viral shedding seen. We did, however, note increased HIV-specific IgA in HIV- negative women with four or more clients per day, and decreased HIV-specific IgA in both long-term non-progressors and long-term survivors. These results show that there is not a strong cohort-wide correlation between HIV-specific cervical IgA levels and resistance to infection by HIV-1 as previously believed, but there is a correlation between exposure to HIV and HIV-specific cervical IgA. Our findings do not preclude the possibility that functional differences in the cervical IgA of HEPS women may play a role in resistance, but argue that HIV-specific responses may not be a universal protective factor. They also indicate that resistance to HIV is a complex condition related to more factors than exposure. Further studies of correlates of immune protection in these individuals would be beneficial to the field.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1089/aid.2008.0207
Copyright Statement Copyright 2009 Mary Ann Liebert, Inc., publishers. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Volume 25
Issue Number 1
Page from 83
Page to 92
ISSN 0889-2229
Date Accessioned 2010-03-09
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Epidemiology; Humoural Immunology and Immunochemistry; Medical Virology
URI http://hdl.handle.net/10072/33893
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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