IgA1 antibodies specific for outer membrane protein PorA modulate the interaction between Neisseria meningitidis and the epithelium

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Title IgA1 antibodies specific for outer membrane protein PorA modulate the interaction between Neisseria meningitidis and the epithelium
Author Horton, Rachel Elizabeth; Vidarsson, G.; Virji, M.; Williams, N.A.; Heyderman, R.S.
Journal Name Microbial Pathogenesis
Year Published 2009
Place of publication United Kingdom
Publisher Elsevier
Abstract Despite high carriage rates of Neisseria meningitidis, incidence of meningococcal disease remains low, partially due to development of natural immunity. We have previously demonstrated an inverse relationship between salivary anti-meningococcal IgA and disease incidence, but little is known about the contribution of IgA to immunity at mucosal surfaces. Here we show strong immunoreactivity by human salivary IgA against the meningococcal outer membrane porin, PorA. Monomeric anti-PorA IgA1 (humanized chimeric antibodies) but not IgG increased the association of unencapsulated serogroup B N. meningitidis (H44/76) with Chang (conjunctival) but not with either Detroit (pharyngeal) cells or with A549 (alveolar) epithelial cells. Association of encapsulated N. meningitidis was not increased. Epithelial binding of IgA was Fc fragment dependent and not inhibited by IgM. Together these data suggest the presence of a specific epithelial IgA receptor that could influence the effect of both naturally acquired and vaccine induced IgA antibodies at the epithelial surface.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.micpath.2009.01.009
Copyright Statement Copyright 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 46
Issue Number 5
Page from 253
Page to 260
ISSN 0882-4010
Date Accessioned 2010-03-09
Date Available 2010-10-08T06:55:15Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Humoural Immunology and Immunochemistry; Medical Bacteriology
URI http://hdl.handle.net/10072/33894
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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