Neuronal oxidative hypometabolism in the brainstem of the epaulette shark(Hemiscyllium ocellatum) in response to hypoxic pre-conditioning

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Title Neuronal oxidative hypometabolism in the brainstem of the epaulette shark(Hemiscyllium ocellatum) in response to hypoxic pre-conditioning
Author Renshaw, Gillian Mary Claire; Mulvey, Jamin.
Journal Name Neuroscience Letters
Year Published 2000
Place of publication Ireland
Publisher Elsevier Science Ireland
Abstract Reduced oxidative demand or neuronal hypometabolism is a neuroprotective strategy used by several anoxia and hypoxia-tolerant species. The epaulette shark, Hemiscyllium ocellatum inhabits shallow reef platforms that can become hypoxic. Hypoxic pre-conditioning (eight cycles of 0.34 mg O2/l for 120 min, 12 h apart) was used to determine whether a reduction in oxidative metabolism could be elicited in the epaulette shark brain. Hypoxic pre-conditioning resulted in a significant overall reduction in oxidative activity in coronal sections of the brainstem, but key nuclei displayed heterogeneous levels of oxidative metabolism. Motor nuclei had significantly lower levels of oxidative activity while sensory nuclei did not. The epaulette shark's ability to enter this state of hypometabolism in response to hypoxic pre-conditioning revealed a neuroprotective mechanism, which would not only reduce neuronal damage during hypoxic exposure but also minimise re-oxygenation injury.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/506081/description#description
Copyright Statement Copyright 2000 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
Volume 290
Page from 1
Page to 4
ISSN 0304-3940
Date Accessioned 2001-01-01
Date Available 2007-03-13T21:47:29Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Subject Central Nervous System; Medical & Health Sciences
URI http://hdl.handle.net/10072/3400
Publication Type Article in Scholarly Refereed Journal
Publication Type Code c1

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