The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes

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Title The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes
Author Srikhanta, Yogitha Nageswary; Fox, Kate L.; Jennings, Michael Paul
Journal Name Nature Reviews: Microbiology
Year Published 2010
Place of publication United Kingdom
Publisher Macmillan Publishers
Abstract In several host-adapted pathogens, phase variation has been found to occur in genes that encode methyltransferases associated with type III restriction–modification systems. It was recently shown that in the human pathogens Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis phase variation of a type III DNA methyltransferase, encoded by members of the mod gene family, regulates the expression of multiple genes. This novel genetic system has been termed the 'phasevarion' (phase-variable regulon). The wide distribution of phase-variable mod family genes indicates that this may be a common strategy used by host-adapted bacterial pathogens to randomly switch between distinct cell types.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1038/nrmicro2283
Volume 8
Issue Number 3
Page from 196
Page to 206
ISSN 1740-1526
Date Accessioned 2010-07-16
Date Available 2010-09-16T08:19:07Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Microbial Genetics
URI http://hdl.handle.net/10072/34029
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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