Intention-to-treat in randomized controlled trials: Recommendations for a total trial strategy

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Title Intention-to-treat in randomized controlled trials: Recommendations for a total trial strategy
Author Polit, Denise F.; Gillespie, Brigid Mary
Journal Name Research in Nursing & Health
Year Published 2010
Place of publication United States
Publisher Wiley
Abstract Intention-to-treat (ITT) in randomized controlled trials involves keeping participants in the treatment groups to which they were randomized regardless of whether they withdraw following randomization. Intention-to-treat is a strategy for maintaining the integrity of randomization and strengthening the trial's internal validity. Although ITT is advocated by the Consolidated Standards of Reporting Trials (CONSORT) guidelines, there is confusion about what ITT means and little specific advice on how to achieve it. The purpose of this article is to present definitions of ITT and to suggest strategies for implementing ITT as a total design strategy in nursing clinical trials. Recommendations are offered regarding study planning, study design, subject retention, sampling, data collection, data analysis, and reporting within the context of ITT.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1002/nur.20386
Volume 33
Issue Number 4
Page from 355
Page to 368
ISSN 0160-6891
Date Accessioned 2010-09-02
Date Available 2010-09-21T06:56:49Z
Language en_AU
Research Centre Centre for Health Practice Innovation; Griffith Health Institute
Faculty Griffith Health Faculty
Subject Nursing
URI http://hdl.handle.net/10072/34148
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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