Effect of dietary selenium on the progression of heart failure in the ageing spontaneously hypertensive rat

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Title Effect of dietary selenium on the progression of heart failure in the ageing spontaneously hypertensive rat
Author Lymbury, Robyn; Marino, Matthew; Perkins, Anthony Vincent
Journal Name Molecular Nutrition & Food Research
Year Published 2010
Place of publication Germany
Publisher Wiley
Abstract Oxidative stress has been directly implicated in hypertension and myocardial remodelling, two pathologies fundamental to the development of chronic heart failure. Selenium (Se) can act directly and indirectly as an antioxidant and a lowered Se status leads to a higher risk of cardiovascular disease. This study examined the role of Se on the development of hypertension and subsequent progression to chronic heart failure in spontaneously hypertensive rats (SHR). Three dietary groups were studied: (i) Se-free; (ii) normal Se (50 μg Se/kg food); and (iii) high Se (1000 μg Se/kg food). Systolic blood pressure and echocardiography were used to detect cardiac changes in vivo. At study end, cardiac tissues were assayed for glutathione peroxidase activity, thioredoxin reductase activity, and protein carbonyls. The major finding of this study was the high heart failure-related mortality rate in SHRs fed an Se-free diet (70%). Normal and high levels of dietary Se resulted in higher survival rates of 78 and 100%, respectively. Furthermore, high dietary Se was clearly associated with lower levels of cardiac oxidative damage and increased antioxidant expression, as well as a reduction in disease severity and mortality in the SHR.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1002/mnfr.201000012
Volume 54
Page from 1
Page to 9
ISSN 1613-4125
Date Accessioned 2010-09-02
Date Available 2011-06-16T06:03:12Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Biochemistry and Cell Biology
URI http://hdl.handle.net/10072/34156
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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