Heart rate variability is related to impaired haemorheology in older women with type 2 diabetes

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Title Heart rate variability is related to impaired haemorheology in older women with type 2 diabetes
Author Simmonds, Michael; Sabapathy, Surendran; Gass, Gregory C.; Marshall-Gradisnik, Sonya M.; Haseler, Luke Jonathon; Christy, Rhys M.; Minahan, Clare Leslie
Journal Name Clinical Hemorheology and Microcirculation
Editor J.-F. Stoltz, S. Forconi, F. Jung, H. Niimi
Year Published 2010
Place of publication Netherlands
Publisher IOS Press
Abstract Impaired heart rate variability (HRV)and haemorheology are independently associated with cardiovascular disease and diabetic complications. The aim of the present study was to investigate the relationships between parameters of HRV,and red blood cell (RBC) aggregation and deformability, in older women with type 2 diabetes. Twenty women (age 69 ± 2 yr) with uncomplicated type 2 diabetes and twenty controls (age 69 ± 3 yr) participated in the study. Beat-to-beat cardiac (RR) intervals over 5 min were analysed for HRV parameters in the time and frequency domains. Blood was sampled for RBC deformability, as well as RBC aggregation in two suspending mediums: haematocrit adjusted plasma and 3% dextran 70. RBC aggregation was increased and HRV was impaired for those with type 2 diabetes when compared with control. RBC aggregation was negatively related to low frequency power of HRV, and was positively related to high frequency power of HRV, for subjects with type 2 diabetes. RBC deformability was positively related to HRV only for those with type 2 diabetes. Impaired haemorheology is associated with reduced HRV in older women with type 2 diabetes, suggesting changes in the microcirculation may result in impaired modulation of cardiac cycles.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.3233/CH-2010-1333
Volume 46
Page from 57
Page to 68
ISSN 1386-0291
Date Accessioned 2010-09-24
Language en_AU
Research Centre Menzies Health Institute Qld; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Cardiovascular Medicine and Haematology
URI http://hdl.handle.net/10072/34329
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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