The effects of long-term honey, sucrose, or sugar-free diets on memory and anxiety in rats

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Title The effects of long-term honey, sucrose, or sugar-free diets on memory and anxiety in rats
Author Chepulis, Lynne; Starkey, Nicola J.; Waas, Joseph R.; Molan, Peter C.
Journal Name Physiology & Behavior
Year Published 2009
Place of publication United States
Publisher Elsevier
Abstract Sucrose is considered by many to be detrimental to health, giving rise to deterioration of the body associated with ageing. This study was undertaken to determine whether replacing sucrose in the diet long-term with honey that has a high antioxidant content could decrease deterioration in brain function during ageing. Forty-five 2-month old Sprague Dawley rats were fed ad libitum for 52 weeks on a powdered diet that was either sugar-free or contained 7.9% sucrose or 10% honey (which is the equivalent amount of sugar). Anxiety levels were assessed using an Elevated Plus Maze, whilst a Y maze and an Object Recognition task were used to assess memory. Locomotor activity was also measured using an Open Field task to ensure that differences in activity levels did not bias results in the other tasks. Anxiety generally decreased overall from 3 to 12 months, but the honey-fed rats showed significantly less anxiety at all stages of ageing compared with those fed sucrose. Honey-fed animals also displayed better spatial memory throughout the 12-month period: at 9 and 12 months a significantly greater proportion of honey-fed rats recognised the novel arm as the unvisited arm of the maze compared to rats on a sugar-free or sucrose-based diet. No significant differences among groups were observed in the Object Recognition task, and there appeared to be no differences in locomotor activity among groups at either 6 or 12 months. In conclusion, it appears that consumption of honey may reduce anxiety and improve spatial memory in middle age.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.physbeh.2009.03.001
Volume 97
Issue Number 3-4
Page from 359
Page to 368
ISSN 0031-9384
Date Accessioned 2009-07-08
Date Available 2010-10-04T06:52:17Z
Language en_AU
Faculty Griffith Health Faculty
Subject Nutritional Physiology
URI http://hdl.handle.net/10072/34361
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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