The pilin O-glycosylation pathway of pathogenic Neisseria is a general system that glycosylates AniA, an outer membrane nitrite reductase

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Title The pilin O-glycosylation pathway of pathogenic Neisseria is a general system that glycosylates AniA, an outer membrane nitrite reductase
Author Ku, S.C.; Shulz, B.L.; Power, P.M.; Jennings, Michael Paul
Journal Name Biochemical and Biophysical Research Communications
Year Published 2009
Place of publication United States
Publisher Elsevier
Abstract O-Glycosylation is emerging as a common posttranslational modification of surface exposed proteins in bacterial mucosal pathogens. In pathogenic Neisseria an O-glycosylation pathway modifies a single abundant protein, pilin, the subunit protein that forms pili. Here, we identify an additional outer membrane glycoprotein in pathogenic Neisseria, the nitrite reductase AniA, that is glycosylated in its C-terminal repeat region by the pilin glycosylation pathway. To our knowledge, this is the first report of a general O-glycosylation pathway in a prokaryote. We also show that AniA displays polymorphisms in residues that map to the surface of the protein. A frame-shift mutation abolishes AniA expression in 34% of Neisseria meningitidis strains surveyed, however, all Neisseria gonorrhoeae strains examined are predicted to express AniA, implying a crucial role for AniA in gonococcal biology.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.bbrc.2008.11.025
Volume 378
Issue Number 1
Page from 84
Page to 89
ISSN 0006-291X
Date Accessioned 2010-02-18
Date Available 2010-10-04T06:54:05Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/34377
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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