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dc.contributor.authorWang, Conan K
dc.contributor.authorPan, Lifeng
dc.contributor.authorChen, Jia
dc.contributor.authorZhang, Mingjie
dc.date.accessioned2017-05-03T15:40:23Z
dc.date.available2017-05-03T15:40:23Z
dc.date.issued2010
dc.date.modified2010-10-06T06:55:27Z
dc.identifier.issn1674-800X
dc.identifier.doi10.1007/s13238-010-0099-6
dc.identifier.urihttp://hdl.handle.net/10072/34404
dc.description.abstractDivide and conquer' has been the guiding strategy for the study of protein structure and function. Proteins are divided into domains with each domain having a canonical structural definition depending on its type. In this review, we push forward with the interesting observation that many domains have regions outside of their canonical definition that affect their structure and function; we call these regions 'extensions'. We focus on the highly abundant PDZ (PSD-95, DLG1 and ZO-1) domain. Using bioinformatics, we find that many PDZ domains have potential extensions and we developed an openly-accessible website to display our results (http://bcz102.ust.hk/pdzex/). We propose, using well-studied PDZ domains as illustrative examples, that the roles of PDZ extensions can be classified into at least four categories: 1) protein dynamics-based modulation of target binding affinity, 2) provision of binding sites for macro-molecular assembly, 3) structural integration of multi-domain modules, and 4) expansion of the target ligand-binding pocket. Our review highlights the potential structural and functional importance of domain extensions, highlighting the significance of looking beyond the canonical boundaries of protein domains in general.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeChina
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom737
dc.relation.ispartofpageto751
dc.relation.ispartofissue8
dc.relation.ispartofjournalProtein & Cell
dc.relation.ispartofvolume1
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchStructural biology (incl. macromolecular modelling)
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310112
dc.titleExtensions of PDZ domains as important structural and functional elements
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorWang, Conan K.


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