Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments

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Title Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments
Author Rogers, Kelly; Grice, Darren; Griffiths, Lyn
Journal Name European Journal of Pharmaceutical Sciences
Year Published 2000
Place of publication Netherlands
Publisher Elsevier Science
Abstract To identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of the seven plants exhibiting significant inhibition of platelet function were reanalysed in the presence of polyvinyl pyrrolidone (PVP) to remove polyphenolic tannins that precipitate proteins. Two of these extracts no longer exhibited inhibition of platelet activity after removal of tannins. However, extracts of Crataegus monogyna, Ipomoea pes-caprae, Eremophila freelingii, Eremophila longifolia, and Asteromyrtus symphyocarpa still potently inhibited ADP induced human platelet [14C]5-HT release in vitro, with levels ranging from 62 to 95% inhibition. I. pes-caprae, and C. monogyna also caused significant inhibition of ADP induced platelet aggregation. All of these plants have been previously used as traditional headache treatments, except for C. monogyna which is used primarily for protective effects on the cardiovascular system. Further studies elucidating the compounds that are responsible for these anti-platelet effects are needed to determine their exact mechanism of action.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/523997/description#description
Copyright Statement Copyright 2000 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
Volume 9
Page from 355
Page to 363
ISSN 0928-0987
Date Accessioned 2001-01-01
Language en_AU
Research Centre Griffith Health Institute; Institute for Glycomics
Subject Medical & Health Sciences
URI http://hdl.handle.net/10072/3449
Publication Type Article in Scholarly Refereed Journal
Publication Type Code c1

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