Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B

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Title Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B
Author Davenport, Victoria; Groves, Eleanor; Horton, Rachel Elizabeth; Hobbs, Christopher G.; Guthrie, Terry; Findlow, Jamie; Borrow, Ray; Næss, Lisbeth M.; Oster, Philipp; Heyderman, Robert S.; Williams, Neil A.
Journal Name Journal of Infectious Diseases
Year Published 2008
Place of publication United States
Publisher University of Chicago Press
Abstract BACKGROUND: Nasopharyngeal carriage of meningococcus or related species leads to protective immunity in adolescence or early adulthood. This natural immunity is associated with mucosal and systemic T cell memory. Whether parenteral Neisseria meningitidis serogroup B (MenB) vaccination influences natural mucosal immunity is unknown. OBJECTIVES: To determine whether parenteral MenB vaccination affects mucosal immunity in young adults and whether this immunity differs from that induced in the blood. METHODS: Otherwise healthy volunteers were immunized with MenB outer membrane vesicle vaccine before and after routine tonsillectomy. Mucosal and systemic immunity were assessed in 9 vaccinees and 12 unvaccinated control subjects by measuring mononuclear cell proliferation, cytokine production, Th1/Th2 surface marker expression, and antibody to MenB antigens. RESULTS: Parenteral vaccination induced a marked increase in systemic T cell immunity against MenB and a Th1 bias. In contrast, although mucosal T cell proliferation in response to MenB neither increased nor decreased following vaccination, mononuclear cell interferon gamma, interleukin (IL)-5, and IL-10 production increased, and the Th1/Th2 profile lost its Th1 bias. CONCLUSIONS: Parenteral MenB vaccination selectively reprograms preexisting naturally acquired mucosal immunity. As new-generation protein-based MenB vaccine candidates undergo evaluation, the impact of these vaccines on mucosal immunity in both adults and children will need to be addressed.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1086/590669
Copyright Statement Copyright 2008 by University of Chicago Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. First published in Journal of Infectious Diseases, 2008;198:731–740. Please refer to the journal's website for access to the definitive, published version.
Volume 198
Issue Number 5
Page from 731
Page to 740
ISSN 0022-1899
Date Accessioned 2010-07-16
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Immunology
URI http://hdl.handle.net/10072/34913
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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