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dc.contributor.authorP. Lutzky, Viviana
dc.contributor.authorCorban, Monika
dc.contributor.authorHeslop, Lea
dc.contributor.authorE. Morrison, Leanne
dc.contributor.authorCrooks, Pauline
dc.contributor.authorF. Hall, David
dc.contributor.authorComan, William
dc.contributor.authorA. Thomson, Scott
dc.contributor.authorJ. Moss, Denis
dc.contributor.editorLynn W Enquist
dc.date.accessioned2017-05-03T15:55:31Z
dc.date.available2017-05-03T15:55:31Z
dc.date.issued2010
dc.date.modified2010-11-12T08:34:13Z
dc.identifier.issn0022538X
dc.identifier.doi10.1128/JVI.01303-09
dc.identifier.urihttp://hdl.handle.net/10072/34983
dc.description.abstractEpstein-Barr virus (EBV) is associated with several malignant diseases including nasopharyngeal carcinoma (NPC), a common neoplasm throughout southeast Asia. Radiotherapy and chemotherapy can achieve remission, but a reemergence of disease is not uncommon. Therefore, there is a need for specific therapies that target the tumor through the recognition of EBV antigens. In NPC, latent membrane protein 1 (LMP1) and LMP2 offer the best opportunity for specific targeting since they are typically expressed and T-cell determinants in each of these proteins have been defined. We have attempted to maximize the opportunity of incorporating every possible CD4 and CD8 determinant in a single formulation. We have achieved this by generating a scrambled protein incorporating random overlapping peptide sets from EBNA1, LMP1, and LMP2, which was then inserted into a replication-deficient strain of adenovirus (adenovirus scrambled antigen vaccine [Ad-SAVINE]). This report describes the construction of this Ad-SAVINE construct, its utility in generating LMP1 and LMP2 responses in healthy individuals as well as NPC patients, and its capacity to define new epitopes. This formulation could have a role in NPC immunotherapy for all ethnic groups since it has the potential to activate all possible CD4 and CD8 responses within EBNA1 and LMPs.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom407
dc.relation.ispartofpageto417
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Virology
dc.relation.ispartofvolume84
dc.rights.retentionY
dc.subject.fieldofresearchClinical Pharmacology and Therapeutics
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111502
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleNovel approach to the formulation of an Epstein-Barr virus antigen-based nasopharyngeal carcinoma vaccine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorComan, William B.


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