Effect of phosphate and temperature on force exerted by white muscle fibres from dogfish

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Title Effect of phosphate and temperature on force exerted by white muscle fibres from dogfish
Author Park-Holohan, S.-J.; West, T. G.; Woledge, R. C.; Ferenczi, M. A.; Barclay, Christopher John; Curtin, N. A.
Journal Name Journal of Muscle Research and Cell Motility
Year Published 2010
Place of publication Netherlands
Publisher Springer
Abstract Effects of Pi (inorganic phosphate) are relevant to the in vivo function of muscle because Pi is one of the products of ATP hydrolysis by actomyosin and by the sarcoplasmic reticulum Ca2+ pump. We have measured the Pi sensitivity of force produced by permeabilized muscle fibres from dogfish (Scyliorhinus canicula) and rabbit. The activation conditions for dogfish fibres were crucial: fibres activated from the relaxed state at 5, 12, and 20°C were sensitive to Pi, whereas fibres activated from rigor at 12°C were insensitive to Pi in the range 5-25 mmol l−1. Rabbit fibres activated from rigor were sensitive to Pi. Pi sensitivity of force produced by dogfish fibres activated from the relaxed state was greater below normal body temperature (12°C for dogfish) in agreement with what is known for other species. The force-temperature relationship for dogfish fibres (intact and permeabilized fibres activated from relaxed) showed that at 12°C, normal body temperature, the force was near to its maximum value.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1007/s10974-010-9198-5
Volume 31
Issue Number 1
Page from 35
Page to 44
ISSN 0142-4319
Date Accessioned 2010-11-03
Date Available 2010-12-08T08:53:42Z
Language en_AU
Research Centre Heart Foundation Research Centre; Griffith Health Institute
Faculty Griffith Health Faculty
Subject Animal Physiology - Cell
URI http://hdl.handle.net/10072/35301
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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