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dc.contributor.authorLiu, A
dc.contributor.authorMenon, S
dc.contributor.authorColson, NJ
dc.contributor.authorQuinlan, S
dc.contributor.authorCox, H
dc.contributor.authorPeterson, M
dc.contributor.authorTiang, T
dc.contributor.authorHaupt, LM
dc.contributor.authorLea, RA
dc.contributor.authorGriffiths, LR
dc.date.accessioned2017-05-03T14:47:57Z
dc.date.available2017-05-03T14:47:57Z
dc.date.issued2010
dc.date.modified2011-01-27T06:44:50Z
dc.identifier.issn1756-0500
dc.identifier.doi10.1186/1756-0500-3-213
dc.identifier.urihttp://hdl.handle.net/10072/35586
dc.description.abstractBackground: The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many diagnostic characteristics in common. It is postulated that migraine symptomatic characteristics might themselves be influenced by MTHFR. Here we analysed the clinical profile, migraine symptoms, triggers and treatments of 267 migraineurs previously genotyped for the MTHFR C677T variant. The chisquare test was used to analyse all potential relationships between genotype and migraine clinical variables. Regression analyses were performed to assess the association of C677T with all migraine clinical variables after adjusting for gender. Findings: The homozygous TT genotype was significantly associated with MA (P < 0.0001) and unilateral head pain (P = 0.002). While the CT genotype was significantly associated with physical activity discomfort (P < 0.001) and stress as a migraine trigger (P = 0.002). Females with the TT genotype were significantly associated with unilateral head pain (P < 0.001) and females with the CT genotype were significantly associated with nausea (P < 0.001), osmophobia (P = 0.002), and the use of natural remedy for migraine treatment (P = 0.003). Conversely, male migraineurs with the TT genotype experienced higher incidences of bilateral head pain (63% vs 34%) and were less likely to use a natural remedy as a migraine treatment compared to female migraineurs (5% vs 20%). Conclusions: MTHFR genotype is associated with specific clinical variables of migraine including unilateral head pain, physical activity discomfort and stress.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent250324 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofjournalBMC Research Notes
dc.relation.ispartofvolume3
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchOther health sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode4299
dc.titleAnalysis of the MTHFR C677T variant with migraine phenotypes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.facultyGriffith Health, School of Medical Science
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 3:213.
gro.rights.copyright© 2010 Liu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorColson, Natalie J.


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