Analysis of the MTHFR C677T variant with migraine phenotypes

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Title Analysis of the MTHFR C677T variant with migraine phenotypes
Author Liu, Annie; Menon, Saras; Colson, Natalie Jane; Quinlan, Sharon Anne; Cox, Hannah; Peterson, Madelyn Mary; Tiang, Thomas; Haupt, Larisa; Lea, Rodney Arthur; Griffiths, Lyn
Journal Name BMC Research Notes
Year Published 2010
Place of publication United Kingdom
Publisher BioMed Central Ltd.
Abstract Background: The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many diagnostic characteristics in common. It is postulated that migraine symptomatic characteristics might themselves be influenced by MTHFR. Here we analysed the clinical profile, migraine symptoms, triggers and treatments of 267 migraineurs previously genotyped for the MTHFR C677T variant. The chisquare test was used to analyse all potential relationships between genotype and migraine clinical variables. Regression analyses were performed to assess the association of C677T with all migraine clinical variables after adjusting for gender. Findings: The homozygous TT genotype was significantly associated with MA (P < 0.0001) and unilateral head pain (P = 0.002). While the CT genotype was significantly associated with physical activity discomfort (P < 0.001) and stress as a migraine trigger (P = 0.002). Females with the TT genotype were significantly associated with unilateral head pain (P < 0.001) and females with the CT genotype were significantly associated with nausea (P < 0.001), osmophobia (P = 0.002), and the use of natural remedy for migraine treatment (P = 0.003). Conversely, male migraineurs with the TT genotype experienced higher incidences of bilateral head pain (63% vs 34%) and were less likely to use a natural remedy as a migraine treatment compared to female migraineurs (5% vs 20%). Conclusions: MTHFR genotype is associated with specific clinical variables of migraine including unilateral head pain, physical activity discomfort and stress.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2010 Liu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Volume 3
Page from 1
Page to 6
ISSN 1756-0500
Date Accessioned 2010-12-02
Language en_AU
Comments Page numbers are not for citation purposes. Instead, this article has the unique article number of 2010, 3:213.
Research Centre Menzies Health Institute Qld
Faculty Griffith Health Faculty
Subject Medical and Health Sciences
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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