GABA(A) receptors alpha-subunit proteins on human chronics alcoholics

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Title GABA(A) receptors alpha-subunit proteins on human chronics alcoholics
Author Lewohl, Joanne M.; Huygens, Flavia; Crane, Denis; Dodd, Peter R.
Journal Name Journal of Neurochemistry
Year Published 2001
Place of publication USA
Publisher Blackwell Science
Abstract Antibodies were raised against specific peptides from N-terminal regions of the ±1 and ±3 isoforms of the GABAA receptor, and used to assess the relative expression of these proteins in the superior frontal and primary motor cortices of 10 control, nine uncomplicated alcoholic and six cirrhotic alcoholic cases were matched for age and post-mortem delay. The regression of expression on post-mortem delay was not statistically significant for either isoform in either region. In both cortical areas, the regression of ±1 expression on age differed significantly between alcoholic cases, which showed a decrease, and normal controls, which did not. Age had no effect on ±3 expression. The ±1 and ±3 isoforms were found to be expressed differentially across cortical regions and showed a tendency to be expressed differentially across case groups. In cirrhotic alcoholics, ±1 expression was greater in superior frontal than in motor cortex, whereas this regional difference was not significant in controls or uncomplicated alcoholics. In uncomplicated alcoholics, ±3 expression was significantly lower in superior frontal than in motor cortex. Expression of ±1 was significantly different from that of ±3 in the superior frontal cortex of alcoholics, but not in controls. In motor cortex, there were no significant differences in expression between the isoforms in any case group.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2001 Blackwell Publishing. The definitive version is available at []
Volume 78
Page from 424
Page to 434
ISSN 0022-3042
Date Accessioned 2002-06-04
Language en_AU
Research Centre Eskitis Institute for Drug Discovery
Subject Neurosciences
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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