Genetics of Menstrual Migraine: The Molecular Evidence
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Author(s)
Colson, Natalie
Fernandez, Francesca
Griffiths, Lyn
Griffith University Author(s)
Year published
2010
Metadata
Show full item recordAbstract
Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss ...
View more >Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss future approaches for analysis with the view to elucidate the complex genetic architecture that underlies the disorder.
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View more >Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss future approaches for analysis with the view to elucidate the complex genetic architecture that underlies the disorder.
View less >
Journal Title
Current Pain and Headache Reports
Volume
14
Issue
5
Copyright Statement
© 2010 Current Medicine Group LLC. Published by Springer. This is an electronic version of an article published in Current Pain and Headache Reports, Volume 14, Number 5, 389-395. Current Pain and Headache Reports is available online at: http://www.informaworld.com/smpp/ with the open URL of your article.
Subject
Clinical sciences
Neurosciences
Pharmacology and pharmaceutical sciences