dc.contributor.author | Leah, John | |
dc.date.accessioned | 2017-05-03T13:33:32Z | |
dc.date.available | 2017-05-03T13:33:32Z | |
dc.date.issued | 2001 | |
dc.date.modified | 2007-03-14T02:36:59Z | |
dc.identifier.issn | 00068993 | |
dc.identifier.uri | http://hdl.handle.net/10072/3560 | |
dc.description.abstract | Stimulation of sensory C-fibres produces extensive expression of the Fos, Jun and Krox families of inducible transcription factors (ITFs) in many nociceptive CNS areas [28]. In the hippocampus, however, c-Fos is only weakly induced by such stimulation, and expression of the other ITFs has not been studied. Here we examine the effects of single, repeated and simultaneous C-fibre inputs on ITF expressions in the rat hippocampus. A brief, strong electrical stimulation of sciatic nerve C-fibres induced little or no expression of c-Fos or Krox-20. In contrast, FosB was induced and continued to rise in all areas, whereas the basal expressions of c-Jun and Krox-24 were initially reduced but then returned during the subsequent 36 h. A weak noxious cutaneous stimulus applied to one hindpaw induced only weak expressions of the ITFs. However, if the sciatic stimulation was applied contralaterally and 6 h beforehand, this weak stimulus strongly induced Krox-24, but not other ITFs, i.e. there was a potentiation of Krox-24 expression. When these two stimuli were applied simultaneously a few c-Fos labelled cells did appear, and there was and an increased Krox-24 expression. There was also a strong potentiation of FosB and a strong reduction in c-Jun expression. This simultaneous stimulation was the only type of stimulation to induce expression of Krox-20. Also after simultaneous stimulation the majority of the nuclear labelling for FosB, but not of the other ITFs, had a speckled appearance. MK-801 blocked these changes in ITF expressions, but it could also cause the C-fibre stimulations to induce c-Fos and c-Jun in specific areas of the hippocampus. Thus C-fibre stimulation does affect transcription factor activity in the hippocampus; and the strong responses of some ITFs to simultaneous inputs points to their having a role as 'genetic coincidence detectors' in the hippocampus. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier Science | |
dc.publisher.place | Netherlands | |
dc.publisher.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/622287/description#description | |
dc.relation.ispartofpagefrom | 193 | |
dc.relation.ispartofpageto | 208 | |
dc.relation.ispartofjournal | Brain Research | |
dc.relation.ispartofvolume | 894 | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Psychology | |
dc.subject.fieldofresearch | Cognitive Sciences | |
dc.subject.fieldofresearchcode | 1109 | |
dc.subject.fieldofresearchcode | 1701 | |
dc.subject.fieldofresearchcode | 1702 | |
dc.title | Jun, Fos and Krox in the hippocampus after noxious stimulation : simultaneous-input-dependent expression and nuclear speckling | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | An Unassigned Group, An Unassigned Department | |
gro.rights.copyright | © 2001 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links. | |
gro.date.issued | 2001 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Leah, John D. | |
gro.griffith.author | Pearse, Damien | |
gro.griffith.author | Mirza, Asim | |