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dc.contributor.authorSingh, P
dc.contributor.authorYam, M
dc.contributor.authorRussell, PJ
dc.contributor.authorKhatri, A
dc.date.accessioned2017-05-03T11:48:06Z
dc.date.available2017-05-03T11:48:06Z
dc.date.issued2010
dc.date.modified2011-01-25T02:19:18Z
dc.identifier.issn0304-3835
dc.identifier.doi10.1016/j.canlet.2009.11.019
dc.identifier.urihttp://hdl.handle.net/10072/35614
dc.description.abstractCastrate resistant prostate cancer (CRPC) is essentially incurable. Recently though, chemotherapy demonstrated a survival benefit (~2 months) in the treatment of CRPC. While this was a landmark finding, suboptimal efficacy and systemic toxicities at the therapeutic doses warranted further development. Smart combination therapies, acting through multiple mechanisms to target the heterogeneous cell populations of PC and with potential for reduction in individual dosing, need to be developed. In that, targeted molecular chemotherapy has generated significant interest with the potential for localized treatment to generate systemic efficacy. This can be further enhanced through the use of oncolytic conditionally replicative adenoviruses (CRAds) to deliver molecular chemotherapy. The prospects of chemotherapy and molecular-chemotherapy as single and as components of combination therapies are discussed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto14
dc.relation.ispartofissue1
dc.relation.ispartofjournalCancer Letters
dc.relation.ispartofvolume293
dc.rights.retentionY
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode321199
dc.titleMolecular and traditional chemotherapy: A united front against prostate cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorSingh, Preetinder P.


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