Molecular and traditional chemotherapy: A united front against prostate cancer

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Title Molecular and traditional chemotherapy: A united front against prostate cancer
Author Singh, Preetinder Pal; Yam, M.; Russell, P.J.; Khatri, A.
Journal Name Cancer Letters
Year Published 2010
Place of publication Ireland
Publisher Elsevier
Abstract Castrate resistant prostate cancer (CRPC) is essentially incurable. Recently though, chemotherapy demonstrated a survival benefit (~2 months) in the treatment of CRPC. While this was a landmark finding, suboptimal efficacy and systemic toxicities at the therapeutic doses warranted further development. Smart combination therapies, acting through multiple mechanisms to target the heterogeneous cell populations of PC and with potential for reduction in individual dosing, need to be developed. In that, targeted molecular chemotherapy has generated significant interest with the potential for localized treatment to generate systemic efficacy. This can be further enhanced through the use of oncolytic conditionally replicative adenoviruses (CRAds) to deliver molecular chemotherapy. The prospects of chemotherapy and molecular-chemotherapy as single and as components of combination therapies are discussed.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.canlet.2009.11.019
Volume 293
Issue Number 1
Page from 1
Page to 14
ISSN 0304-3835
Date Accessioned 2010-12-15
Date Available 2011-01-25T02:19:18Z
Language en_AU
Faculty Griffith Health Faculty
Subject Oncology and Carcinogenesis
URI http://hdl.handle.net/10072/35614
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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