(+)-7-Bromotrypargine: an antimalarial b-carboline from the Australian marine sponge Ancorina sp.

There are no files associated with this record.

Title (+)-7-Bromotrypargine: an antimalarial b-carboline from the Australian marine sponge Ancorina sp.
Author Davis, Rohan Andrew; Duffy, Sandra; Avery, Vicky Marie; Camp, David Brian; Hooper, John N.A.; Quinn, Ronald J.
Journal Name Tetrahedron Letters
Year Published 2010
Place of publication UK
Publisher Elsevier
Abstract Mass-directed isolation of the CH2Cl2/MeOH extract from the Australian marine sponge Ancorina sp. resulted in the purification of a new antimalarial β-carboline, (+)-7-bromotrypargine 1, along with the previously isolated natural product, 6-bromotryptamine 2. The structure of 1 is determined by extensive 1D/2D NMR and MS data analyses. Comparison of the chiro-optical data for 1 with literature values of related natural products is used to determine the absolute stereochemistry of (+)-7-bromotrypargine as 1R. Antimalarial activity data for 1 and 2 against a chloroquine-resistant (Dd2) and chloroquine-sensitive (3D7) Plasmodium falciparum strain are also provided.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.tetlet.2009.11.055
Volume 51
Issue Number 4
Page from 583
Page to 585
ISSN 0040-4039
Date Accessioned 2010-10-21
Language en_AU
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Biologically Active Molecules
URI http://hdl.handle.net/10072/35929
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

Show simple item record

Griffith University copyright notice