dc.contributor.author | Davis, Rohan A | |
dc.contributor.author | Demirkiran, Ozlem | |
dc.contributor.author | Sykes, Melissa L | |
dc.contributor.author | Avery, Vicky M | |
dc.contributor.author | Suraweera, Lekha | |
dc.contributor.author | Fechner, Gregory A | |
dc.contributor.author | Quinn, Ronald J | |
dc.date.accessioned | 2018-09-19T01:30:44Z | |
dc.date.available | 2018-09-19T01:30:44Z | |
dc.date.issued | 2010 | |
dc.date.modified | 2011-02-02T06:55:55Z | |
dc.identifier.issn | 0960-894X | |
dc.identifier.doi | 10.1016/j.bmcl.2010.05.091 | |
dc.identifier.uri | http://hdl.handle.net/10072/35941 | |
dc.description.abstract | Mass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal a-pyrone, 7',8'-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 卮 | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Pergamon | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 4057 | |
dc.relation.ispartofpageto | 4059 | |
dc.relation.ispartofissue | 14 | |
dc.relation.ispartofjournal | Bioorganic & Medicinal Chemistry Letters | |
dc.relation.ispartofvolume | 20 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Biologically active molecules | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340401 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.title | 7′,8′-Dihydroobolactone, a typanocidal α-pyrone from the rainforest tree Cryptocarya obovata | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2010 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Quinn, Ronald J. | |
gro.griffith.author | Davis, Rohan A. | |
gro.griffith.author | Sykes, Melissa L. | |
gro.griffith.author | Avery, Vicky M. | |