Functional test of the influence of Wolbachia genes on cytoplasmic incompatibility expression in Drosophila melanogaster

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Title Functional test of the influence of Wolbachia genes on cytoplasmic incompatibility expression in Drosophila melanogaster
Author Yamada, R.; Iturbe-Ormaetxe, I.; Brownlie, Jeremy; O'Neill, S. L.
Journal Name Insect Molecular Biology
Year Published 2010
Place of publication United Kingdom
Publisher Wiley-Blackwell
Abstract Wolbachia are inherited intracellular bacteria that infect a broad range of invertebrate hosts. They commonly manipulate host reproduction in a variety of ways and thereby favour their invasion into host populations. While the biology of Wolbachia has been extensively studied at the ecological and phenotypic level, little is known about the molecular mechanisms underlying the interaction between Wolbachia and their hosts. Recent comparative genomics studies of Wolbachia strains have revealed putative candidate genes involved in the expression of cytoplasmic incompatibility (CI) in insects. However the functional testing of these genes is hindered by the lack of available genetic tools in Wolbachia. To circumvent this problem we generated transgenic Drosophila lines expressing various Wolbachia CI candidate genes under the control of the GAL4/UAS system in order to evaluate their possible role in Wolbachia-related phenotypes in Drosophila. The expression of a number of these genes in Drosophila melanogaster failed to mimic or alter CI phenotypes across a range of Wolbachia backgrounds or in the absence of Wolbachia.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1111/j.1365-2583.2010.01042.x
Volume 20
Issue Number 1
Page from 75
Page to 85
ISSN 1365-2583
Date Accessioned 2011-02-01
Date Available 2011-02-14T09:14:13Z
Language en_AU
Research Centre Environmental Futures Research Institute
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/36169
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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