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Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase

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Title Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase
Author Kok, Gaik B; Campbell, Michael; Mackey, Brendan L; von Itzstein, Mark
Journal Name Carbohydrate Research
Year Published 2001
Place of publication UK
Publisher Pergamon
Abstract The synthesis of 3-azido-3-deoxy, 3-amino-3-deoxy and 3-N-tert-butyloxycarbonyl-3-deoxy derivatives of 2-acetamido-2-deoxy-±,²--mannose (N-acetyl-±,²--mannosamine, ManNAc), is presented. The 3-azido-3-deoxy- and 3-N-tert-butyloxycarbonyl compounds were further characterised as their peracetates. A preliminary study has found that these C-3 nitrogen-substituted derivatives of ManNAc not to be substrates for Neu5Ac aldolase.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/424829/description#description
Copyright Statement Copyright 2001 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
Volume 332
Issue Number 2
Page from 133
Page to 139
ISSN 0008-6215
Date Accessioned 2002-04-22
Date Available 2007-03-14T02:34:13Z
Language en_AU
Research Centre Institute for Glycomics
Subject Organic Chemical Synthesis
URI http://hdl.handle.net/10072/3669
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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