Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase

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Title Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase
Author Kok, Gaik B; Campbell, Michael; Mackey, Brendan L; von Itzstein, Mark
Journal Name Carbohydrate Research
Year Published 2001
Place of publication UK
Publisher Pergamon
Abstract The synthesis of 3-azido-3-deoxy, 3-amino-3-deoxy and 3-N-tert-butyloxycarbonyl-3-deoxy derivatives of 2-acetamido-2-deoxy-α,β--mannose (N-acetyl-α,β--mannosamine, ManNAc), is presented. The 3-azido-3-deoxy- and 3-N-tert-butyloxycarbonyl compounds were further characterised as their peracetates. A preliminary study has found that these C-3 nitrogen-substituted derivatives of ManNAc not to be substrates for Neu5Ac aldolase.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/S0008-6215(01)00091-X
Volume 332
Issue Number 2
Page from 133
Page to 139
ISSN 0008-6215
Date Accessioned 2002-04-22
Date Available 2015-05-04T22:04:33Z
Language en_US
Research Centre Institute for Glycomics
Subject PRE2009-Organic Chemical Synthesis
URI http://hdl.handle.net/10072/3669
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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