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dc.contributor.authorYin, Sheng
dc.contributor.authorBoyle, Glen M
dc.contributor.authorCarroll, Anthony R
dc.contributor.authorKotiw, Michael
dc.contributor.authorDearnaley, John
dc.contributor.authorQuinn, Ronald J
dc.contributor.authorDavis, Rohan A
dc.date.accessioned2017-05-03T12:46:44Z
dc.date.available2017-05-03T12:46:44Z
dc.date.issued2010
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np100329w
dc.identifier.urihttp://hdl.handle.net/10072/36773
dc.description.abstractFour new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent160262 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1586
dc.relation.ispartofpageto1589
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume73
dc.rights.retentionN
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchNatural products and bioactive compounds
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340502
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titleCaelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian aplidium caelestis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright 2010 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np100329w.
gro.date.issued2015-07-30T23:08:55Z
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorCarroll, Anthony R.


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