Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian aplidium caelestis

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Title Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian aplidium caelestis
Author Yin, Sheng; Boyle, Glen M.; Carroll, Anthony Richard; Kotiw, Michael; Dearnaley, John; Quinn, Ronald J.; Davis, Rohan Andrew
Journal Name Journal of Natural Products
Year Published 2010
Place of publication United States
Publisher American Chemical Society
Abstract Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1021/np100329w
Copyright Statement Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Volume 73
Issue Number 9
Page from 1586
Page to 1589
ISSN 0163-3864
Date Accessioned 2010-10-27
Date Available 2011-04-11T06:48:21Z
Language en_AU
Research Centre Environmental Futures Research Institute; Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Natural Products Chemistry
URI http://hdl.handle.net/10072/36773
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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