Anti-Influenza virus drug design: Sialidase inhibitors
Author(s)
Dyason, JC
von Itzstein, M
Griffith University Author(s)
Year published
2001
Metadata
Show full item recordAbstract
This review will give an overview of the design process behind the development of sialidase inhibitors, which can be used as anti-influenza drugs. Two drugs (Relenza頡nd Tamiflu驠are already available as prescription drugs and a third (BCX-1812) is currently undergoing third-phase clinical trials. Also, the use of molecular-modelling techniques in the understanding of the mechanism and the prediction of inhibition of this enzyme is reviewed.This review will give an overview of the design process behind the development of sialidase inhibitors, which can be used as anti-influenza drugs. Two drugs (Relenza頡nd Tamiflu驠are already available as prescription drugs and a third (BCX-1812) is currently undergoing third-phase clinical trials. Also, the use of molecular-modelling techniques in the understanding of the mechanism and the prediction of inhibition of this enzyme is reviewed.
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Journal Title
Australian Journal of Chemistry
Volume
54
Issue
11
Publisher URI
Subject
Chemical sciences