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Anti-Influenza virus drug design: Sialidase inhibitors

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Title Anti-Influenza virus drug design: Sialidase inhibitors
Author Dyason, Jeffrey Clifford; von Itzstein, Mark
Journal Name Australian Journal of Chemistry
Year Published 2001
Place of publication Australia
Publisher CSIRO Publishing
Abstract This review will give an overview of the design process behind the development of sialidase inhibitors, which can be used as anti-influenza drugs. Two drugs (Relenza™ and Tamiflu™) are already available as prescription drugs and a third (BCX-1812) is currently undergoing third-phase clinical trials. Also, the use of molecular-modelling techniques in the understanding of the mechanism and the prediction of inhibition of this enzyme is reviewed.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.publish.csiro.au/nid/51.htm
Alternative URI http://www.publish.csiro.au/nid/51/paper/CH01173.htm
Copyright Statement Copyright 2001 CSIRO : This is the author-manuscript version of this paper. Please refer to the journal link for access to the definitive, published version.
Volume 54
Issue Number 11
Page from 663
Page to 670
ISSN 0004-9425
Date Accessioned 2002-04-22
Date Available 2009-12-10T08:46:38Z
Language en_AU
Research Centre Institute for Glycomics
Subject PRE2009-Organic Chemical Synthesis
URI http://hdl.handle.net/10072/3678
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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