R-(–)-β-O-methylsynephrine, a natural product, inhibits VEGF-induced angiogenesis in vitro and in vivo

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Title R-(–)-β-O-methylsynephrine, a natural product, inhibits VEGF-induced angiogenesis in vitro and in vivo
Author Kim, Nam Hee; Pham, Ngoc Bich; Quinn, Ronald J; Kwon, Ho Jeong
Journal Name Biochemical and Biophysical Research Communications
Year Published 2010
Place of publication United States
Publisher Elsevier
Abstract R-(–)-β-O-methylsynephrine (OMe-Syn) is an active compound isolated from a plant of the Rutaceae family. We conducted cell proliferation assays on various cell lines and found that OMe-Syn more strongly inhibited the growth of human umbilical vein endothelial cells (HUVECs) than that of other normal and cancer cell lines tested. In angiogenesis assays, it inhibited vascular endothelial growth factor (VEGF)-induced invasion and tube formation of HUVECs with no toxicity. The anti-angiogenic activity of OMe-Syn was also validated in vivo using the chorioallantonic membrane (CAM) assay in growing chick embryos. Expression of the growth factors VEGF, hepatocyte growth factor, and basic fibroblast growth factor was suppressed by OMe-Syn in a dose-dependent manner. Taken together, our results indicate that this compound could be a novel basis for a small molecule targeting angiogenesis
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.bbrc.2010.07.025
Volume 399
Issue Number 1
Page from 20
Page to 23
ISSN 0006-291X
Date Accessioned 2010-11-11
Date Available 2011-03-07T08:52:41Z
Language en_AU
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Biologically Active Molecules
URI http://hdl.handle.net/10072/36840
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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