Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds

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Title Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds
Author Bisht, Kavita; Wagner, Karl-Heinz; Bulmer, Andrew Cameron
Journal Name Toxicology
Year Published 2010
Place of publication Ireland
Publisher Elsevier Ireland Ltd
Abstract Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant products have health promoting effects emerged because their intake was related to a reduced incidence of cancer, cardiovascular, neurological, respiratory, and age-related diseases. Exposure of the body to a stressful environment challenges cell survival and increases the risk of chronic disease developing. The polyphenols afford protection against various stress-induced toxicities through modulating intercellular cascades which inhibit inflammatory molecule synthesis, the formation of free radicals, nuclear damage and induce antioxidant enzyme expression. These responses have the potential to increase life expectancy. The present review article focuses on curcumin, resveratrol, and flavonoids and seeks to summarize their anti-inflammatory, cytoprotective and DNA-protective properties.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.tox.2009.11.008
Copyright Statement Copyright 2010 Elsevier Ireland Ltd. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 278
Issue Number 1
Page from 88
Page to 100
ISSN 0300-483X
Date Accessioned 2011-01-27
Date Available 2011-07-06T10:05:48Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Pharmacology and Pharmaceutical Sciences
URI http://hdl.handle.net/10072/36884
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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