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dc.contributor.authorTran, Trong D
dc.contributor.authorPham, Ngoc B
dc.contributor.authorFechner, Gregory
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2017-05-03T11:47:04Z
dc.date.available2017-05-03T11:47:04Z
dc.date.issued2010
dc.date.modified2011-03-07T08:56:24Z
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2010.07.100
dc.identifier.urihttp://hdl.handle.net/10072/36953
dc.description.abstractTwo of the four parameters in the 'rule of five', molecular weight and log P, which can be detected and predicted by mass spectrometry and compound retention on reversed-phase HPLC, were used as guidelines in natural product isolation. A new aporphine alkaloid, (6aR)-normecambroline (1), was isolated from the bark of Neolitsea dealbata (R. Br.) Merr. Its structure was determined on the basis of NMR, MS and CD analysis. It is the first time the absolute configuration of the roemerine-N-oxide was assigned for both roemerine-Na-oxide (3) and roemerine-N߭oxide (4). Physico-chemical property evaluation demonstrated all alkaloids had no Lipinski violation. Compound 1 inhibited selectively against cervical cancer cells (HeLa) with an IC50 of 4.0 卮
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom5859
dc.relation.ispartofpageto5863
dc.relation.ispartofissue19
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume20
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.titleChemical investigation of drug-like compounds from the Australian tree, Neolitsea dealbata
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.


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