Isolation of bioactive compounds that relate to the anti-platelet activity of Cymbopogon ambiguus

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Title Isolation of bioactive compounds that relate to the anti-platelet activity of Cymbopogon ambiguus
Author Grice, Darren; Rogers, Kelly; Griffiths, Lyn
Journal Name Evidence-Based Complementary and Alternative Medicine
Year Published 2011
Place of publication United Kingdom
Publisher Hindawi Publishing Corporation
Abstract Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant’s anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 mM, in comparison to aspirin, with an IC50 value of 46.1 mM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2010 Oxford University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 2011
Page from 1
Page to 8
ISSN 1741-427X
Date Accessioned 2010-12-22
Language en_US
Research Centre Menzies Health Institute Qld; Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Complementary and Alternative Medicine
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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