Aspartate chemosensory receptor signalling in Campylobacter jejuni

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Title Aspartate chemosensory receptor signalling in Campylobacter jejuni
Author Korolik, Victoria
Journal Name Virulence
Year Published 2010
Place of publication United States
Publisher Landes Bioscience
Abstract The human bacterial pathogen Campylobacter jejuni is able to respond to environmental stimuli utilising chemotactic motility. The bacterial senses external molecules via transmembrane sensory proteins called Transducer Like Proteins, TLPs. The specificity of the Tlp1 chemoreceptor (Cj1506c) of C. jejuni as the aspartate receptor, CcaA, and its role in chemotaxis signalling pathway were characterised by genetic and biochemical approaches including amino acid and small molecule arrays, Saturation Transfer Difference NMR spectroscopy, and mutational analysis. Yeast two-hybrid and three-hybrid analysis of protein-protein interactions showed that CcaA chemotactic signal was preferentially passed through CheV, rather than the CheW homologue of the chemotaxis signalling pathway allowing a new model for the C. jejuni chemotactic signalling pathway to be postulated.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.4161/viru.1.5.12735
Copyright Statement Copyright remains with the author 2010. This is the author-manuscript version of this paper. It is posted here with permission of the copyright owner for your personal use only. No further distribution permitted. For information about this journal please refer to the journal's website or contact the author.
Volume 1
Issue Number 5
Page from 417
Page to 420
ISSN 2150-5594
Date Accessioned 2011-01-13
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/37549
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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