The interaction between respiratory viruses and pathogenic bacteria in the upper respiratory tract of asymptomatic Aboriginal and non-Aboriginal children

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Title The interaction between respiratory viruses and pathogenic bacteria in the upper respiratory tract of asymptomatic Aboriginal and non-Aboriginal children
Author Moore, Hannah C.; Jacoby, Peter; Taylor, Amanda; Harnett, Gerry; Bowman, Jacinta; Riley, Thomas V.; Reuter, Kelly; Smith, David W.; Lehmann, Deborah; Aalberse, J.; Alpers, K.; Arumugaswamy, A.; Beissbarth, J.; Bonney, P.; Bonney, R.; Brestovac, B.; Carter, J.; Carville, K.; Coates, H.; Coleman, S.; Cripps, Allan W; Dorizzi, L.; Dunn, D.; Elsbury, D.; Edwards, E.; Evans, J.; Finucane, J.; Firth, M.; Forrest, A.; al, et
Journal Name Pediatric Infectious Disease Journal
Year Published 2010
Place of publication United States
Publisher Lippincott Williams and Wilkins
Abstract Background: Associations between respiratory viruses and the bacterial pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis may be important in the pathogenesis of otitis media (OM). However, data on asymptomatic identification rates of respiratory viruses are limited, particularly in Indigenous populations, who suffer a high burden of OM. Methods: We describe the identification of respiratory viruses alone and in combination with pathogenic OM bacteria in 1006 nasopharyngeal aspirates collected from asymptomatic Aboriginal and non-Aboriginal children in a longitudinal community-based cohort study in rural Western Australia. Results: Viruses were identified in 42% of samples from Aboriginal and 32% from non-Aboriginal children. Rhinoviruses were the most frequently identified virus with higher identification rates in Aboriginal (23.6%) than non-Aboriginal children (16.5%; P = 0.003). Rhinoviruses were associated with H. influenzae (odds ratio [OR], 2.24; 95% CI, 1.24–4.07 for Aboriginal children) and M. catarrhalis (OR, 1.94; 95% CI, 1.05–3.57 for Aboriginal children). Adenoviruses were positively associated with H. influenzae in Aboriginal children (OR, 3.30; 95% CI, 1.19–9.09) and M. catarrhalis in non-Aboriginal children (OR, 5.75; 95% CI, 1.74–19.23), but negatively associated with S. pneumoniae in Aboriginal children (OR, 0.39; 95% CI, 0.18–0.84). Conclusions: We found a high identification rate of rhinoviruses and adenoviruses in asymptomatic children. The associations between these viruses and OM bacteria have implications for preventive strategies targeted at specific pathogens.
Peer Reviewed Yes
Published Yes
Publisher URI http://journals.lww.com/pidj/Abstract/2010/06000/The_Interaction_Between_Respiratory_Viruses_and.14.aspx
Copyright Statement Copyright 2010 Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in the Pediatric Infectious Disease Journal, Vol. 29(6), pp. 540-545. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal link for access to the definitive, published version.
Volume 29
Issue Number 6
Page from 540
Page to 545
ISSN 0891-3668
Date Accessioned 2011-02-09
Date Available 2011-08-12T06:19:22Z
Language en_AU
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Immunology
URI http://hdl.handle.net/10072/37590
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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