Complexity in Influenza Virus Targeted Drug Design: Interaction with Human Sialidases

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Title Complexity in Influenza Virus Targeted Drug Design: Interaction with Human Sialidases
Author Chavas, Leonard M. G.; Kato, Ryuichi; Suzuki, Nobuhiro; von Itzstein, Mark; Mann, Maretta; Thomson, Robin Joy; Dyason, Jeffrey Clifford; McKimm-Breschkin, Jennifer; Fusi, Paola; Tringali, Cristina; Venerando, Bruno; Tettamanti, Guido; Monti, Eugenio; Wakatsuki, Soichi
Journal Name Journal of Medicinal Chemistry
Year Published 2010
Place of publication United States
Publisher American Chemical Society
Abstract With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1021/jm100078r
Copyright Statement Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 53
Issue Number 7
Page from 2998
Page to 3002
ISSN 0022-2623
Date Accessioned 2011-01-25
Date Available 2011-03-23T05:44:50Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medicinal and Biomolecular Chemistry
URI http://hdl.handle.net/10072/37591
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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