Complexity in Influenza Virus Targeted Drug Design: Interaction with Human Sialidases
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| Title | Complexity in Influenza Virus Targeted Drug Design: Interaction with Human Sialidases |
|---|---|
| Author | Chavas, Leonard M. G.; Kato, Ryuichi; Suzuki, Nobuhiro; von Itzstein, Mark; Mann, Maretta; Thomson, Robin Joy; Dyason, Jeffrey Clifford; McKimm-Breschkin, Jennifer; Fusi, Paola; Tringali, Cristina; Venerando, Bruno; Tettamanti, Guido; Monti, Eugenio; Wakatsuki, Soichi |
| Journal Name | Journal of Medicinal Chemistry |
| Year Published | 2010 |
| Place of publication | United States |
| Publisher | American Chemical Society |
| Abstract | With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds. |
| Peer Reviewed | Yes |
| Published | Yes |
| Alternative URI | http://dx.doi.org/10.1021/jm100078r |
| Copyright Statement | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information. |
| Volume | 53 |
| Issue Number | 7 |
| Page from | 2998 |
| Page to | 3002 |
| ISSN | 0022-2623 |
| Date Accessioned | 2011-01-25 |
| Date Available | 2011-03-23T05:44:50Z |
| Language | en_AU |
| Research Centre | Institute for Glycomics |
| Faculty | Faculty of Science, Environment, Engineering and Technology |
| Subject | Medicinal and Biomolecular Chemistry |
| URI | http://hdl.handle.net/10072/37591 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1 |
Please use this identifier to cite this record: http://hdl.handle.net/10072/37591
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