Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells

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Title Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells
Author Reiman, Jennifer M.; Knutson, Keith; Radisky, Derek
Journal Name Cancer Research
Year Published 2010
Place of publication United States
Publisher American Association for Cancer Research
Abstract Elements of the immune system act as intimate regulators of cancer progression, inhibiting early stages of tumor growth, through immunosurveillance while facilitating later stages of tumor progression. Recent findings have revealed that activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal transition (EMT) and to acquire the greatly increased tumorigenic capability and chemotherapeutic resistance of breast cancer stem cells (BCSC). These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1158/0008-5472.CAN-09-4041
Volume 70
Issue Number 8
Page from 3005
Page to 3008
ISSN 1538-7445
Date Accessioned 2011-03-16
Date Available 2011-03-23T05:48:02Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Tumour Immunology
URI http://hdl.handle.net/10072/37678
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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