ROS Receptor Tyrosine Kinase: A New Potential Target for Anticancer Drugs

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Title ROS Receptor Tyrosine Kinase: A New Potential Target for Anticancer Drugs
Author El-Deeb, Ibrahim Mustafa; Yoo, Kyung Ho; Lee, So Ha
Journal Name Medicinal Research Reviews
Year Published 2010
Place of publication United States
Publisher Wiley interscience
Abstract ROS kinase is one of the last two remaining orphan receptor tyrosine kinases with an as yet unidentified ligand. The normal functions of human ROS kinase in different body tissues have not been fully identified so far. However, the ectopic expression, as well as the production of variable mutant forms of ROS kinase has been reported in a number of cancers, such as glioblastoma multiforme, and non-small cell lung cancer, suggesting a role for ROS kinase in deriving such tumors. It is thought also that c-ROS gene may have a role in some cardiovascular diseases, and the fact that homozygous male mice targeted against c-ROS gene are healthy but infertile, has inspired researchers to think about ROS inhibition as a method for development of new male contraceptives. The recent discovery of new selective and potent inhibitors for ROS kinase, along with the development of new specific diagnostic methods for the detection of ROS fusion proteins, raises the importance of using these selective inhibitors for targeting ROS mutations as a new method for treatment of cancers harboring such genes. This review focuses on the ectopic expression of ROS and its fusion proteins in different cancer types and highlights the importance of targeting these proteins for treatment of substantial cancers. It describes also the recent advances in the field of ROS kinase inhibition, and the potential clinical applications of ROS kinase inhibitors.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1002/med.20206
Copyright Statement Copyright 2010 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article: ROS Receptor Tyrosine Kinase: A New Potential Target for Anticancer Drugs, Medicinal Research Reviews, which has been published in final form at http://dx.doi.org/10.1002/med.20206.
Volume na
Page from 1
Page to 25
ISSN 0198-6325
Date Accessioned 2011-03-18
Date Available 2011-07-20T07:06:36Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Pharmaceutical Sciences
URI http://hdl.handle.net/10072/37836
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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