Correlation between bioluminescence and bacterial burden in passively protected mice challenged with a recombinant bioluminescent M49 group A streptococcus Strain

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Title Correlation between bioluminescence and bacterial burden in passively protected mice challenged with a recombinant bioluminescent M49 group A streptococcus Strain
Author Sheel, Meru; Pandey, Manisha; Good, Michael Francis; Batzloff, Michael Raymond
Journal Name Clinical and vaccine immunology
Year Published 2010
Place of publication United States
Publisher American Society for Microbiology
Abstract Streptococcus pyogenes, also known as group A streptococcus (GAS), is a human pathogen which infects people of all age groups. Previous work has reported that conformationally constrained chimeric peptide J8 protects against GAS challenge. In the current study, we demonstrate the utility of bioluminescent imaging as a rapid technique for monitoring bacterial dissemination following the passive transfer of rabbit anti-J8 antibodies to naïve mice and subsequent challenge with recombinant GAS strain M49, an emm type shown to be associated with poststreptococcal glomerular nephritis.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1128/CVI.00256-09
Volume 17
Issue Number 1
Page from 127
Page to 133
ISSN 1556-6811
Date Accessioned 2011-03-21
Date Available 2014-01-08T05:29:56Z
Language en_US
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/37849
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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